Its focus is the visual arts and culture of the American South within the context of the region's history and culture.
It is associated with the University of New Orleans.
The collection consists of work by artists from or associated with fifteen southern states and the District of Columbia.
It is based upon the founding donation of more than 1,100 works from New Orleans businessman Roger H. Ogden's private collection.
Since this original donation the museums collection of paintings, watercolors, drawings, prints, photographs, sculpture, wood and crafts has grown to include more than 4,000 works donated from individuals and collectors from across the US.
The collection is the largest and most comprehensive collection of Southern art in the world and embodies the visual heritage and history of the American South from 1733 to the present.
The Museum has permanent galleries and changing exhibitions throughout the year.