Displays in the museum depict the cultural history and the lifestyle of the people of the Klein Karoo region, and the museum prides itself on its replica of an early 20th century pharmacy.

There is a section of the museum devoted to the role of the Jewish community in the development of Oudtshoorn's feather industry.

The C.P Nel Museum is an independent, registered museum located in Graaff-Reinet, South Africa. It is named after the renowned Afrikaans poet and journalist, Cornelis Petrus Nel, and it houses an important collection of South African and international art. The museum has a permanent collection of over 1000 artworks and a variety of temporary exhibitions. It also hosts several educational programmes and events throughout the year. The museum was established in 1975 and is housed in a historic building that was built in 1813.

It has a wide range of artworks from South African and international artists, including works from the Dutch Golden Age, the German Expressionists, and the Russian Avant-Garde. The museum also has several works by contemporary South African artists. The permanent collection includes sculptures, paintings, photographs, and installations. The C.P Nel Museum also hosts a variety of educational programmes, as well as a number of events throughout the year. These include artist talks, workshops, and performances. The museum also has a library which houses over 8000 books and periodicals related to the arts, history, and culture. The museum also has a sculpture garden which features works by local and international artists.